期刊
NATURE NEUROSCIENCE
卷 17, 期 12, 页码 1655-1657出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3846
关键词
-
资金
- US National Institutes of Health [DA003906, DA012513, DA015369]
Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
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