期刊
NATURE NEUROSCIENCE
卷 17, 期 3, 页码 407-415出版社
NATURE RESEARCH
DOI: 10.1038/nn.3647
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资金
- INSERM
- EU-Fp7 (REPROBESITY) [HEALTH-F2-2008-223713]
- European Research Council (ENDOFOOD) [ERC-2010-StG-260515]
- Fondation pour la Recherche Medicale [FRM-DRM-20101220445]
- Region Aquitaine
- LABEX BRAIN [ANR-10-LABX-43]
- Fyssen Foundation
- EMBO Post-doc Fellowship
- RTA, I.S. Carlos III [RD12/0028/0004]
- Basque Country Government [BCG IT764-13]
- University of the Basque Country [UFI11/41]
- MINECO [BFU2012-33334, SAF2012-35759]
- Postdoctoral Specialization Contract from the University of the Basque Country UPV/EHU
- Deutsche Forschungsgemeinschaft [SFB-TRR 58]
- CONACyT
- AG2R-La-Mondiale
Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
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