期刊
NATURE NEUROSCIENCE
卷 16, 期 9, 页码 1199-U64出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3485
关键词
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资金
- Spanish Ministry of Economy and Innovation (MINECO) [SAF2011-28845, BFU2011-23049]
- CONSOLIDER [CSD2007-00023]
- European Research Council [ERC-2011-AdG 293683]
- MINECO
- European Molecular Biology Organization (EMBO)
In the cerebral cortex, pyramidal cells and interneurons are generated in distant germinal zones, and so the mechanisms that control their precise assembly into specific microcircuits remain an enigma. Here we report that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex. This behavior is common to different classes of interneurons, independently of their origin. Interneuron clusters are typically contained within one or two adjacent cortical layers, are largely formed by isochronically generated neurons and populate specific layers, as revealed by unbiased hierarchical clustering methods. Our results suggest that different progenitor cells give rise to interneurons populating infra- and supragranular cortical layers, which challenges current views of cortical neurogenesis. Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization.
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