期刊
NATURE NEUROSCIENCE
卷 16, 期 9, 页码 1179-U25出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3493
关键词
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资金
- US National Institutes of Health [DC008983, EY019049]
- David and Lucile Packard Foundation
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.
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