期刊
NATURE NEUROSCIENCE
卷 15, 期 12, 页码 1736-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3257
关键词
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资金
- US National Institutes of Health [P50 MH084051, R01-MH044340, P50-MH052354]
- John D. and Catherine T. MacArthur Foundation Research Network on Psychopathology and Development
- HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin School of Medicine and Public Health
- Canadian Institutes for Health Research
Early life stress (ELS) and function of the hypothalamic-pituitary-adrenal axis predict later psychopathology. Animal studies and cross-sectional human studies suggest that this process might operate through amygdala-ventromedial prefrontal cortex (vmPFC) circuitry implicated in the regulation of emotion. Here we prospectively investigated the roles of ELS and childhood basal cortisol amounts in the development of adolescent resting-state functional connectivity (rs-FC), assessed by functional connectivity magnetic resonance imaging (fcMRI), in the amygdala-PFC circuit. In females only, greater ELS predicted increased childhood cortisol levels, which predicted decreased amygdala-vmPFC rs-FC 14 years later. For females, adolescent amygdala-vmPFC functional connectivity was inversely correlated with concurrent anxiety symptoms but positively associated with depressive symptoms, suggesting differing pathways from childhood cortisol levels function through adolescent amygdala-vmPFC functional connectivity to anxiety and depression. These data highlight that, for females, the effects of ELS and early HPA-axis function may be detected much later in the intrinsic processing of emotion-related brain circuits.
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