期刊
NATURE NEUROSCIENCE
卷 15, 期 11, 页码 1485-1487出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3233
关键词
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资金
- National Institute of Neurological Disorders and Stroke [NS069375-01A1]
- Department of Veterans Affairs
- US National Institutes of Health Institute on Aging [R01 AG027505]
- California Initiative for Regenerative Medicine
- National Science Foundation
- Ruth L. Kirschstein NRSA [1 F31 AG040877-01A1]
- Swiss National Science Foundation [PBBEB-117034, PASMP3-123221/1]
- Evelyn L. Neizer Fund
- American Heart Association [AHA 083527N]
- Bechtel Foundation
- Swiss National Science Foundation (SNF) [PASMP3-123221] Funding Source: Swiss National Science Foundation (SNF)
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.
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