期刊
NATURE NEUROSCIENCE
卷 15, 期 10, 页码 1359-1361出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3204
关键词
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资金
- US Department of Defense in the Center for Neuroscience and Regenerative Medicine
- US National Institutes of Health grants [AA019454, AA017668, AA020911, AA021043]
- US Department of Defense grant [PT090344]
- US National Alliance for Research on Schizophrenia and Depression
- Bowles Center for Alcohol Studies
- US National Institute on Alcohol Abuse and Alcoholism Intramural Research Program
Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.
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