期刊
NATURE NEUROSCIENCE
卷 15, 期 12, 页码 1700-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3260
关键词
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资金
- US National Institutes of Health [NS065915]
- American Heart Association [0930067N]
- Feldstein Medical Foundation
- State University of New York Research Excellence in Academic Health
- Canadian Institutes of Health Research [MOP86762, MOP74650]
Accumulating evidence suggests that global depletion of adult hippocampal neurogenesis influences its function and that the timing of the depletion affects the deficits. However, the behavioral roles of adult-born neurons during their establishment of projections to CA3 pyramidal neurons remain largely unknown. We used a combination of retroviral and optogenetic approaches to birth date and reversibly control a group of adult-born neurons in adult mice. Adult-born neurons formed functional synapses on CA3 pyramidal neurons as early as 2 weeks after birth, and this projection to the CA3 area became stable by 4 weeks in age. Newborn neurons at this age were more plastic than neurons at other stages. Notably, we found that reversibly silencing this cohort of similar to 4-week-old cells after training, but not cells of other ages, substantially disrupted retrieval of hippocampal memory. Our results identify a restricted time window for adult-born neurons essential in hippocampal memory retrieval.
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