期刊
NATURE NEUROSCIENCE
卷 15, 期 8, 页码 1074-1077出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3168
关键词
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资金
- US National Institutes of Health
- National Multiple Sclerosis Society
- Williams Family Fund for MS Research
Multiple sclerosis (MS) is a spontaneous, acquired, inflammatory demyelinating disease of the human CNS. Because it involves a complex interaction between two of the most intricate biological systems, immune system and CNS, animal modeling has been critical for addressing MS pathogenesis. MS models were originally developed serendipitously more than 75 years ago. Immune-mediated, toxic, viral and genetic models of demyelination are now used to understand the manifold aspects of MS. MS treatments evolved in part from animal model research, and further progress is envisaged in large part because these systems have been continually refined and their use focused on questions whose relevance was established by studying the human disease.
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