期刊
NATURE NEUROSCIENCE
卷 15, 期 9, 页码 1211-U64出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3184
关键词
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资金
- RIKEN
- Ministry of Education, Science, Sports and Culture, Japan [21390122, 22122005]
- Grants-in-Aid for Scientific Research [24111003, 22390096, 21390122, 24700358, 22122005, 24111001] Funding Source: KAKEN
Cell migration is fundamental to organogenesis. During development, the enteric neural crest cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize the entire length of the gut, which undergoes substantial growth and morphological rearrangement. How ENCCs adapt to such changes during migration, however, is not fully understood. Using time-lapse imaging analyses of mouse ENCCs, we show that a population of ENCCs crosses from the midgut to the hindgut via the mesentery during a developmental time period in which these gut regions are transiently juxtaposed, and that such 'trans-mesenteric' ENCCs constitute a large part of the hindgut ENS. This migratory process requires GDNF signaling, and evidence suggests that impaired trans-mesenteric migration of ENCCs may underlie the pathogenesis of Hirschsprung disease (intestinal aganglionosis). The discovery of this trans-mesenteric ENCC population provides a basis for improving our understanding of ENS development and pathogenesis.
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