期刊
NATURE NEUROSCIENCE
卷 15, 期 3, 页码 367-369出版社
NATURE PORTFOLIO
DOI: 10.1038/nn.3037
关键词
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资金
- Genentech
- The Rockefeller University
Axons travel to their targets in bundles or fascicles, but the molecules regulating fasciculation remain incompletely characterized. We found that Slit2 and its Robo receptors are expressed by motor axons, and that inactivation of Slit2 or Robo1 and Robo2 in mice caused axons to defasciculate prematurely at muscle targets. In vitro, Slit2 secreted by motoneurons regulated fasciculation through Robo1 and Robo2. These results support the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mechanism.
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