期刊
NATURE NEUROSCIENCE
卷 15, 期 8, 页码 1108-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3147
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资金
- US National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (US National Institutes of Health)
- Financiadora de Estudos e Projetos/Ministerio de Ciencia e Tecnologia (FINEP/MCT, Brazil)
- Instituto Nacional de Ciencia e Tecnologia em Excitotoxicidade e Neuroprotecao (Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil)
It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine. In AgRP circuit-impaired mice, ventral tegmental dopamine neurons exhibited enhanced spike timing-dependent long-term potentiation, altered amplitude of miniature postsynaptic currents and elevated dopamine in basal forebrain. Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors.
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