期刊
NATURE NEUROSCIENCE
卷 14, 期 12, 页码 1507-1509出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2954
关键词
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资金
- National Institute on Alcohol Abuse
- Alcoholism Intramural Research Program [Z01-AA000411]
Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.
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