期刊
NATURE NEUROSCIENCE
卷 14, 期 9, 页码 1109-1111出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2895
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资金
- US National Institutes of Health [DC009433, HL087120, DC010362, DC008417, DA015040, K12/GM000680]
- Deafness Research Foundation
- German Research Foundation (Collaborative Research Center) [889, A5]
- German Research Foundation (Center for Molecular Physiology of the Brain) [FZT-103]
- German Federal Ministry for Research and Technology (Bernstein Center for Computational Neuroscience Goettingen) [01GQ1005A]
- Alexander von Humboldt fellowship
Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca2+ channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.
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