期刊
NATURE NEUROSCIENCE
卷 14, 期 9, 页码 1118-1120出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2880
关键词
-
资金
- US National Institutes of Health [R01 NS045130-05]
The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
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