期刊
NATURE NEUROSCIENCE
卷 14, 期 8, 页码 1089-U195出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2879
关键词
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资金
- Max Planck Society
Multiphoton imaging (MPI) is widely used for recording activity simultaneously from many neurons in superficial cortical layers in vivo. We combined regenerative amplification multiphoton microscopy (RAMM) with genetically encoded calcium indicators to extend MPI of neuronal population activity into layer 5 (L5) of adult mouse somatosensory cortex. We found that this approach could be used to record and quantify spontaneous and sensory-evoked activity in populations of L5 neuronal somata located as much as 800. m below the pia. In addition, we found that RAMM could be used to simultaneously image activity from large (similar to 80) populations of apical dendrites and follow these dendrites down to their somata of origin.
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