期刊
NATURE NEUROSCIENCE
卷 14, 期 5, 页码 627-U121出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2790
关键词
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资金
- INSERM
- CNRS
- AP-HP
- Federation pour la Recherche Medicale
- Federation pour la Recherche sur le Cerveau
- Agence Nationale de la Recherche
- European Community (EPICURE) [LSH-037315]
- Spain-France Joint Action [HF2006-0082]
- Spanish National Research Council (Consejo Superior de Investigaciones Cientificas) [200720I023]
- Spanish Ministry of Innovation and Science [BFU2006-10584-BFI, BFU2009-07989]
The mechanisms involved in the transition to an epileptic seizure remain unclear. To examine them, we used tissue slices from human subjects with mesial temporal lobe epilepsies. Ictal-like discharges were induced in the subiculum by increasing excitability along with alkalinization or low Mg2+. During the transition, distinct pre-ictal discharges emerged concurrently with interictal events. Intracranial recordings from the mesial temporal cortex of subjects with epilepsy revealed that similar discharges before seizures were restricted to seizure onset sites. In vitro, pre-ictal events spread faster and had larger amplitudes than interictal discharges and had a distinct initiation site. These events depended on glutamatergic mechanisms and were preceded by pyramidal cell firing, whereas interneuron firing preceded interictal events that depended on both glutamatergic and depolarizing GABAergic transmission. Once established, recurrence of these pre-ictal discharges triggered seizures. Thus, the subiculum supports seizure generation, and the transition to seizure involves an emergent glutamatergic population activity.
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