期刊
NATURE NEUROSCIENCE
卷 14, 期 9, 页码 1112-1114出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2893
关键词
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资金
- American Health Assistance Foundation
- US National Institutes of Health/National Institute of Neurological Disorders and Stroke [R01 NS55804]
- Veteran's Affairs Office of Research and Development Medical Research Service
Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's disease.
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