期刊
NATURE NEUROSCIENCE
卷 14, 期 11, 页码 1398-1405出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2946
关键词
-
资金
- US National Institutes of Health [R37 AG023084, R37 NS34467, HL63290]
- Zilkha family
Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.
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