期刊
NATURE NEUROSCIENCE
卷 14, 期 2, 页码 200-U285出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2728
关键词
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资金
- US National Institutes of Health [NS-046064]
- National Alliance for Research on Schizophrenia and Depression
- Northwestern University
The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a similar duration. Although axonal action potential firing was required to trigger persistent firing, somatic depolarization was not. In paired recordings, persistent firing was not restricted to the stimulated neuron; it could also be produced in the unstimulated cell. Thus, these interneurons can slowly integrate spiking, share the output across a coupled network of axons and respond with persistent firing even in the absence of input to the soma or dendrites.
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