期刊
NATURE NEUROSCIENCE
卷 13, 期 8, 页码 920-922出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2572
关键词
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资金
- National Institute of Mental Health
- US National Institutes of Health
- Deutsche Forschungsgemeinschaft-National Institutes of Health [To 539/1-1]
Structural remodeling has been observed in the human brain over periods of weeks to months, but the molecular mechanisms governing this process remain incompletely characterized. Using multimodal pharmaco-neuroimaging, we found that acute D-2 receptor blockade induced reversible striatal volume changes and structural-functional decoupling in motor circuits within hours; these alterations predicted acute extrapyramidal motor symptoms with high precision. Our findings suggest a role for D-2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans.
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