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Mind bomb 1-expressing intermediate progenitors generate Notch signaling to maintain radial glial cells
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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
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Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
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dp5/HRK is a c-jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons
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Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
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NATURE (2007)
Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells
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Neural stem cells in mammalian development
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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms
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Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
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NEURON (2006)
F-box proteins: the key to protein degradation
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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
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NATURE (2005)
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Notch signaling in the mammalian central nervous system: insights from mouse mutants
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Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
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Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor
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Radial glia serve as neuronal progenitors in all regions of the central nervous system
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NEURON (2004)
Defective cardiovascular development and elevated cyclin E and notch proteins in mice lacking the Fbw7 F-box protein
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Mouse Fbw7/Sel-10/Cdc4 is required for Notch degradation during vascular development
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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling
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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
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The AP-1 transcription factor c-jun is required for efficient axonal regeneration
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A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
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JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
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DEVELOPMENTAL CELL (2003)
Impaired intervertebral disc formation in the absence of Jun
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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
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Characterization of CNS precursor subtypes and radial glia
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DEVELOPMENTAL BIOLOGY (2001)
Radial glial identity is promoted by Notch1 signaling in the murine forebrain
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