期刊
NATURE NEUROSCIENCE
卷 13, 期 5, 页码 567-U74出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2528
关键词
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资金
- Huntington Disease Society of America
- US National Institutes of Health National Institute on Aging [AG021904, AG031782, DK041918, T32AG023475]
- National Institute of Neurological Disorders and Stroke Udall Center of Excellence
- Glenn Foundation
- Picower and Simons foundation
- Hereditary Disease Foundation
- Fulbright fellowship
Continuous turnover of intracellular components by autophagy is necessary to preserve cellular homeostasis in all tissues. Alterations in macroautophagy, the main process responsible for bulk autophagic degradation, have been proposed to contribute to pathogenesis in Huntington's disease (HD), a genetic neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin protein. However, the precise mechanism behind macroautophagy malfunction in HD is poorly understood. In this work, using cellular and mouse models of HD and cells from humans with HD, we have identified a primary defect in the ability of autophagic vacuoles to recognize cytosolic cargo in HD cells. Autophagic vacuoles form at normal or even enhanced rates in HD cells and are adequately eliminated by lysosomes, but they fail to efficiently trap cytosolic cargo in their lumen. We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells.
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