期刊
NATURE NEUROSCIENCE
卷 13, 期 7, 页码 805-811出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2575
关键词
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资金
- US National Institutes of Health, National Institute on Aging [AG021904, AG031782]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK041918]
- National Institute of Neurological Disorders and Stroke [NS038370]
- Glenn Foundation
- Hirsch/Weill-Caulier Career Scientist Award
- Hereditary Disease Foundation
Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly linked to a growing number of neurodegenerative disorders. The reasons behind autophagic failure in degenerating neurons can be very diverse because of the different steps required for autophagy and the characterization of the molecular players involved in each of them. Understanding the step(s) affected in the autophagic process in each disorder could explain differences in the course of these pathologies and will be essential to developing targeted therapeutic approaches for each disease based on modulation of autophagy. Here we present examples of different types of autophagic dysfunction described in common neurodegenerative disorders and discuss the prospect of exploring some of the recently identified autophagic variants and the interactions among autophagic and non-autophagic proteolytic systems as possible future therapeutic targets.
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