期刊
NATURE NEUROSCIENCE
卷 13, 期 11, 页码 1351-1353出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2642
关键词
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资金
- Pratt Foundation
- Israel Science Foundation
- Nella and Leon Benoziyo Center for Neurosciences
- Nella and Leon Benoziyo Center for Neurological Diseases
- Carl and Micaela Einhorn-Dominic Brain Research Institute
- Irwin Green Alzheimer's Research Fund
- Gerhard and Hannah Bacharach
DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.
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