期刊
NATURE NEUROSCIENCE
卷 13, 期 3, 页码 287-289出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2500
关键词
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资金
- US National Institutes of Health [R01NS045702, K99NS057944, P30HD40677]
- Department of Education and Science of the Spanish Government
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
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