期刊
NATURE NEUROSCIENCE
卷 14, 期 1, 页码 25-27出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2699
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资金
- US National Institutes of Health [P50 MH078028, T32 MH64913, F31 MH080547]
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH065215, F31MH080547, T32MH064913, P50MH078028] Funding Source: NIH RePORTER
Using real-time gene expression imaging and behavioral analysis, we found that the perinatal photoperiod has lasting effects on the circadian rhythms expressed by clock neurons as well as on mouse behavior, and sets the responsiveness of the biological clock to subsequent changes in photoperiod. These developmental gene x environment interactions tune circadian clock responses to subsequent seasonal photoperiods and may contribute to the influence of season on neurobehavioral disorders in humans.
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