4.7 Article

AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex

期刊

NATURE NEUROSCIENCE
卷 12, 期 10, 页码 1229-U38

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2399

关键词

-

资金

  1. Deutsche Forschungsgemeinschaft
  2. Bundesministerium fur Bildung und Forschung
  3. Bavarian government
  4. Portuguese Fundacao para a Ciencia e Tecnologia/ European Social Fund
  5. MRC [MC_U117570528] Funding Source: UKRI
  6. Medical Research Council [MC_U117570528] Funding Source: researchfish

向作者/读者索取更多资源

An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2 gamma regulates laminar fate in a region-specific manner. Deletion of AP2 gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2 gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2 gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2 gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据