期刊
NATURE NEUROSCIENCE
卷 12, 期 7, 页码 897-U115出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2338
关键词
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资金
- Centre National de la Recherche Scientifique
- Conseil Regional d'Aquitaine
- Ministere de la Recherche
- Fondation pour la Recherche Medicale
- European Commission [CT-2005-005320]
- Deutsche Forschungsgemeinschaft [GU230/5-2/5-3]
- A. v. Humboldt Foundation
- Max Planck Society
- Swiss National Fonds
Many synapses in the mature CNS are wrapped by a dense extracellular matrix (ECM). Using single-particle tracking and fluorescence recovery after photobleaching, we found that this net-like ECM formed surface compartments on rat primary neurons that acted as lateral diffusion barriers for AMPA-type glutamate receptors. Enzymatic removal of the ECM increased extrasynaptic receptor diffusion and the exchange of synaptic AMPA receptors. Whole-cell patch-clamp recording revealed an increased pairedpulse ratio as a functional consequence of ECM removal. These results suggest that the surface compartments formed by the ECM hinder lateral diffusion of AMPA receptors and may therefore modulate short-term synaptic plasticity.
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