期刊
NATURE NEUROSCIENCE
卷 12, 期 3, 页码 247-249出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2282
关键词
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资金
- Action Concertee Incitative Neurosciences, Agence Nationale de la Recherche (Neuro-GRADA)
- European Union Sixth Framework Programme (STREP-PheCOMP)
- Centre National de la Recherche ATIPE
- Fondation pour la Recherche Medicale
- Mission Interministerielle de Lutte contre la Drogue et la Toxicomanie
- NRJ-Foundation
- European Union Sixth Framework Programme (STREP-NovelTune)
- Deutsche Forschungsgemeinschaft [SFB636]
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.
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