4.7 Article

The quest for action potentials in C. elegans neurons hits a plateau

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NATURE NEUROSCIENCE
卷 12, 期 4, 页码 377-378

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NATURE RESEARCH
DOI: 10.1038/nn0409-377

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  1. NIMH NIH HHS [R21 MH112105, R01 MH051383] Funding Source: Medline
  2. NINDS NIH HHS [R01 NS047715] Funding Source: Medline

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The small size and high resistance of C. elegans neurons makes them sensitive to the random opening of single ion channels, probably rendering codes that are based on classical, all-or-none action potentials unworkable. The recent discovery in C. elegans of a special class of regenerative events known as plateau potentials introduces the possibility of digital neural codes. Such codes would solve the problem of representing information in nervous systems in which action potentials are unreliable.

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