期刊
NATURE NEUROSCIENCE
卷 12, 期 11, 页码 1431-1437出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2429
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资金
- Agence Nationale de la Recherche 'Neurosciences, neurologie et psychiatrie'
- European Union 6th framework project 'EUCLOCK'
- Ministere de l'Enseignement Superieur et de la Recherche and Fondation pour le Recherche Medicale
- Ministere de l'Enseignement Superieur et de la Recherche and Association pour la Recherche sur le Cancer
- Institut National de la Sante et des Etudes et Recherches Medicale
Morning and evening circadian oscillators control the bimodal activity of Drosophila in light-dark cycles. The lateral neurons evening oscillator (LN-EO) is important for promoting diurnal activity at dusk. We found that the LN-EO autonomously synchronized to light-dark cycles through either the cryptochrome (CRY) that it expressed or the visual system. In conditions in which CRY was not activated, flies depleted for pigment-dispersing factor (PDF) or its receptor lost the evening activity and displayed reversed PER oscillations in the LN-EO. Rescue experiments indicated that normal PER cycling and the presence of evening activity relied on PDF secretion from the large ventral lateral neurons and PDF receptor function in the LN-EO. The LN-EO thus integrates light inputs and PDF signaling to control Drosophila diurnal behavior, revealing a new clock-independent function for PDF.
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