期刊
NATURE NEUROSCIENCE
卷 12, 期 10, 页码 1308-U135出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2389
关键词
-
资金
- Friedrich Miescher Institute
- US Office of Naval Research Naval International Cooperative Opportunities in Science and Technology
- Marie Curie Excellence Grant, a Human Frontier Science Program
- National Centers of Competence in Research in Genetics
- European Union [HEALTH-F2-223156]
- Marie Curie Postdoctoral Fellowship
- Centre National de la Recherche Scientifique through the Unite Mixte de Recherche [8550]
The detection of approaching objects, such as looming predators, is necessary for survival. Which neurons and circuits mediate this function? We combined genetic labeling of cell types, two-photon microscopy, electrophysiology and theoretical modeling to address this question. We identify an approach-sensitive ganglion cell type in the mouse retina, resolve elements of its afferent neural circuit, and describe how these confer approach sensitivity on the ganglion cell. The circuit's essential building block is a rapid inhibitory pathway: it selectively suppresses responses to non-approaching objects. This rapid inhibitory pathway, which includes All amacrine cells connected to bipolar cells through electrical synapses, was previously described in the context of night-time vision. In the daytime conditions of our experiments, the same pathway conveys signals in the reverse direction. The dual use of a neural pathway in different physiological conditions illustrates the efficiency with which several functions can be accommodated in a single circuit.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据