期刊
NATURE NEUROSCIENCE
卷 13, 期 1, 页码 120-U293出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2453
关键词
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资金
- National Institute of Mental Health [Z01MH-01092]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21119513]
- Japan Society for the Promotion of Science
- NATIONAL INSTITUTE OF MENTAL HEALTH [Z01MH001092, ZIAMH001092] Funding Source: NIH RePORTER
The frontal pole cortex (FPC) expanded markedly during human evolution, but its function remains uncertain in both monkeys and humans. Accordingly, we examined single-cell activity in this area. On every trial, monkeys decided between two response targets on the basis of a 'stay' or 'shift' cue. Feedback followed at a fixed delay. FPC cells did not encode the monkeys' decisions when they were made, but did so later on, as feedback approached. This finding indicates that the FPC is involved in monitoring or evaluating decisions. Using a control task and delayed feedback, we found that decision coding lasted until feedback only when the monkeys combined working memory with sensory cues to 'self-generate' decisions, as opposed to when they simply followed trial-by-trial instructions. A role in monitoring or evaluating self-generated decisions could account for FPC's expansion during human evolution.
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