期刊
NATURE NEUROSCIENCE
卷 12, 期 9, 页码 1087-1089出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2382
关键词
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资金
- James S. McDonnell Foundation [220020180]
- US National Institutes of Health [CA114197, CA107193]
- NATIONAL CANCER INSTITUTE [R01CA114197, R01CA107193] Funding Source: NIH RePORTER
Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
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