To ED or not to ED - Is erectile dysfunction in obstructive sleep apnea related to endothelial dysfunction?

Both obstructive sleep apnea (USA) and erectile dysfunction (ErectD) are highly prevalent and largely under diagnosed medical conditions. These disorders often co-exist, with about half of the male USA population having ErectD and vice versa. USA is strongly associated with an increased risk of cardiovascular mortality while ErectD has been proposed as a phenotypic marker of cardiovascular disease. This implies that the two conditions may be linked by a common pathophysiological mechanism. In this review we provide evidence supporting the hypothesis that endothelial dysfunction (EndoD) may be the common pathophysiological mechanism linking USA with both ErectD and cardiovascular complications. EndoD is one of the earliest markers of cardiovascular disease and substantial evidence suggests that USA independently causes EndoD. There is also strong evidence that causally links EndoD with organic ErectD. Further research should be directed at determining the value of simultaneously assessing both ErectD and USA in patients presenting with symptoms of either condition. In both ErectD and USA clinics, identifying both conditions could improve overall cardiovascular risk stratification whilst treatment of USA could reduce both ErectD and cardiovascular risk. (C) 2014 Published by Elsevier Ltd.