期刊
NATURE NEUROSCIENCE
卷 12, 期 11, 页码 1367-1369出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2403
关键词
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资金
- Leon Levy Foundation
- [NIH-NICHD-HD33402]
- [NSF-IOB-0544406]
- [NIH-NIDCD-DC009910]
- [NIH-NIDA DA0032]
- [NIH-NIMH MH080603]
Behavioral transitions characterize development. Young infant rats paradoxically prefer odors that are paired with shock, but older pups learn aversions. This transition is amygdala and corticosterone dependent. Using microarrays and microdialysis, we found downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone-injected 8-d-old pups and untreated 12-d-old pups learned aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions, whereas dopamine antagonism reinstated preference learning.
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