期刊
NATURE NEUROSCIENCE
卷 11, 期 3, 页码 251-253出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn2047
关键词
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资金
- NINDS NIH HHS [R37 NS027036-22, NS 27036, R37 NS027036-23, R37 NS027036, R01 NS027036] Funding Source: Medline
Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS.
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