期刊
NATURE NEUROSCIENCE
卷 11, 期 3, 页码 327-333出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn2048
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资金
- NEI NIH HHS [R01 EY014429, R01 EY014429-05, R01 EY014429-01A2] Funding Source: Medline
A basic question in the field of motor control is how different actions are represented by activity in spinal projection neurons. We used a new behavioral assay to identify visual stimuli that specifically drive basic motor patterns in zebrafish. These stimuli evoked consistent patterns of neural activity in the neurons projecting to the spinal cord, which we could map throughout the entire population using in vivo two-photon calcium imaging. We found that stimuli that drive distinct behaviors activated distinct subsets of projection neurons, consisting, in some cases, of just a few cells. This stands in contrast to the distributed activation seen for more complex behaviors. Furthermore, targeted cell by cell ablations of the neurons associated with evoked turns abolished the corresponding behavioral response. This description of the functional organization of the zebrafish motor system provides a framework for identifying the complete circuit underlying a vertebrate behavior.
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