期刊
NATURE NEUROSCIENCE
卷 11, 期 4, 页码 417-419出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn2050
关键词
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资金
- NICHD NIH HHS [P01 HD036379, P01 HD036379-120007, P01 HD036379-130007] Funding Source: Medline
- NIDA NIH HHS [R21 DA023643, R21 DA023643-01, R21 DA023643-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 067826, R01 DK067826-04, R01 DK067826] Funding Source: Medline
- NIMH NIH HHS [R01 MH62723, R01 MH062723] Funding Source: Medline
Central serotonin-producing neurons are heterogeneous differing in location, morphology, neurotoxin sensitivity and associated clinical disorders - but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.
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