期刊
NATURE NEUROSCIENCE
卷 11, 期 8, 页码 957-965出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2144
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资金
- NIMH NIH HHS [P50 MH077970-010006, P50 MH077970] Funding Source: Medline
- NINDS NIH HHS [P01 NS034835-09, P02 NS34835-09, F32 NS010414, R01 NS010414-33, NS-10414, P01 NS034835, R01 NS010414] Funding Source: Medline
During early brain development and through 'adult' experience-dependent plasticity, neural circuits are shaped to represent the external world with high fidelity. When raised in a quiet environment, the rat primary auditory cortex (A1) has a well-defined 'critical period', lasting several days, for its representation of sound frequency. The addition of environmental noise extends the critical period duration as a variable function of noise level. It remains unclear whether critical period closure should be regarded as a unified, externally gated event that applies for all of A1 or if it is controlled by progressive, local, activity-driven changes in this cortical area. We found that rearing rats in the presence of a spectrally limited noise band resulted in the closure of the critical period for A1 sectors representing the noise-free spectral bands, whereas the critical period appeared to remain open in noise-exposed sectors, where the cortex was still functionally and physically immature.
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