期刊
NATURE NANOTECHNOLOGY
卷 9, 期 12, 页码 1040-1046出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2014.246
关键词
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资金
- European Commission [IST-2001-38951, FP6-029192, FP7-ERC226628]
- European Science Foundation COST [MP0802]
- Israel Science Foundation [1145/10, 1589/14]
- Binational Science Foundation (BSF) [2006422]
- Minerva Center for Bio-Hybrid complex systems
- Institute for Advanced Studies of the Hebrew University of Jerusalem
- Italian Institute of Technology project MOPROSURF
- Fondazione Cassa di Risparmio di Modena
- Office of Naval Research [N00014-09-1-1117]
- National Science Foundation [CHE-1057953]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [2006422] Funding Source: National Science Foundation
DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.
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