期刊
NATURE NANOTECHNOLOGY
卷 9, 期 8, 页码 639-647出版社
NATURE PORTFOLIO
DOI: 10.1038/NNANO.2014.154
关键词
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资金
- National Science Foundation Career Award [0747577]
- National Institutes of Health Autoimmunity Center of Excellence Pilot Award [U19 AI056363]
- Yale Specialized Programs of Research Excellence (SPORE) Investigator Pilot Award
- Yale SPORE in Skin Cancer [1 P50 CA121974]
Clinical translation of cell therapies requires strategies that can manufacture cells efficiently and economically. One promising way to reproducibly expand T cells for cancer therapy is by attaching the stimuli for T cells onto artificial substrates with high surface area. Here, we show that a carbon nanotube-polymer composite can act as an artificial antigen-presenting cell to efficiently expand the number of T cells isolated from mice. We attach antigens onto bundled carbon nanotubes and combined this complex with polymer nanoparticles containing magnetite and the T-cell growth factor interleukin-2 (IL-2). The number of T cells obtained was comparable to clinical standards using a thousand-fold less soluble IL-2. T cells obtained from this expansion were able to delay tumour growth in a murine model for melanoma. Our results show that this composite is a useful platform for generating large numbers of cytotoxic T cells for cancer immunotherapy.
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