期刊
NATURE NANOTECHNOLOGY
卷 7, 期 2, 页码 119-125出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2011.217
关键词
-
资金
- NIH [5DP1OD003900]
Nanopores could potentially be used to perform single-molecule DNA sequencing at low cost and with high throughput(1-4). Although single base resolution and differentiation have been demonstrated with nanopores using ionic current measurements(5-7), direct sequencing has not been achieved because of the difficulties in recording very small (similar to pA) ionic currents at a bandwidth consistent with fast translocation speeds(1-3). Here, we show that solid-state nanopores can be combined with silicon nanowire field-effect transistors to create sensors in which detection is localized and self-aligned at the nanopore. Well-defined field-effect transistor signals associated with DNA translocation are recorded when an ionic strength gradient is imposed across the nanopores. Measurements and modelling show that field-effect transistor signals are generated by highly localized changes in the electrical potential during DNA translocation, and that nanowire-nanopore sensors could enable large-scale integration with a high intrinsic bandwidth.
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