期刊
NATURE NANOTECHNOLOGY
卷 4, 期 10, 页码 688-694出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nnano.2009.231
关键词
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资金
- National Institute of Health [R0IEB000873, R01EB009230, R01CA131164, R21EB005123, R21CA139373]
- National Science Foundation [DBI-0852737, CMMI-0709121]
- Arkansas Biosciences Institute
- NATIONAL CANCER INSTITUTE [R01CA131164, R21CA139373] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000873, R01EB009230, R21EB005123] Funding Source: NIH RePORTER
- Direct For Biological Sciences [0852737] Funding Source: National Science Foundation
Carbon nanotubes have shown promise as contrast agents for photoacoustic and photothermal imaging of tumours and infections because they offer high resolution and allow deep tissue imaging. However, in vivo applications have been limited by the relatively low absorption displayed by nanotubes at near-infrared wavelengths and concerns over toxicity. Here, we show that gold-plated carbon nanotubes-termed golden carbon nanotubes-can be used as photoacoustic and photothermal contrast agents with enhanced near-infrared contrast (similar to 10(2)-fold) for targeting lymphatic vessels in mice using extremely low laser fluence levels of a few mJ cm(-2). Antibody-conjugated golden carbon nanotubes were used to map the lymphatic endothelial receptor, and preliminary in vitro viability tests show golden carbon nanotubes have minimal toxicity. This new nanomaterial could be an effective alternative to existing nanoparticles and fluorescent labels for non-invasive targeted imaging of molecular structures in vivo.
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