期刊
NATURE NANOTECHNOLOGY
卷 3, 期 4, 页码 216-221出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nnano.2008.68
关键词
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资金
- NCI NIH HHS [U54 CA119367, P50 CA114747] Funding Source: Medline
Single-walled carbon nanotubes are currently under evaluation in biomedical applications, including in vivo delivery(1-3) of drugs(4), proteins, peptides(5-7) and nucleic acids(8,9) ( for gene transfer(10) or gene silencing(11)), in vivo tumour imaging(12) and tumour targeting of single-walled carbon nanotubes as an anti-neoplastic treatment5. However, concerns about the potential toxicity of single-walled carbon nanotubes have been raised(13,14). Here we examine the acute and chronic toxicity of functionalized single-walled carbon nanotubes when injected into the bloodstream of mice. Survival, clinical and laboratory parameters reveal no evidence of toxicity over 4 months. Upon killing, careful necropsy and tissue histology show age-related changes only. Histology and Raman microscopic mapping demonstrate that functionalized single-walled carbon nanotubes persisted within liver and spleen macrophages for 4 months without apparent toxicity. Although this is a preliminary study with a small group of animals, our results encourage further confirmation studies with larger groups of animals.
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