期刊
NATURE METHODS
卷 11, 期 10, 页码 1058-1063出版社
NATURE PORTFOLIO
DOI: 10.1038/nmeth.3098
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资金
- US National Institutes of Health (NIH) [NEI F32 EY022294]
- US National Science Foundation [BCS1228397]
- Human Connectome Project, WU-Minn Consortium [1U54MH091657 NIH]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [1228397] Funding Source: National Science Foundation
Diffusion-weighted imaging coupled with tractography is currently the only method for in vivo mapping of human white-matter fascicles. Tractography takes diffusion measurements as input and produces the connectome, a large collection of white-matter fascicles, as output. We introduce a method to evaluate the evidence supporting connectomes. Linear fascicle evaluation (LiFE) takes any connectome as input and predicts diffusion measurements as output, using the difference between the measured and predicted diffusion signals to quantify the prediction error. We use the prediction error to evaluate the evidence that supports the properties of the connectome, to compare tractography algorithms and to test hypotheses about tracts and connections.
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