期刊
NATURE METHODS
卷 12, 期 2, 页码 123-U148出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3209
关键词
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资金
- US National Institutes of Health [R01 DC02281]
- National Science Foundation [USA GRFP 2012147612]
- Boston Children's Hospital startup funds
- Takeda New Frontier Science
We introduce a nanoscale experimental platform that enables kinetic and equilibrium measurements of a wide range of molecular interactions using a gel electrophoresis readout. Programmable, self-assembled DNA nanoswitches serve both as templates for positioning molecules and as sensitive, quantitative reporters of molecular association and dissociation. We demonstrated this low-cost, versatile, 'lab-on-a-molecule' system by characterizing ten different interactions, including a complex four-body interaction with five discernible states.
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