4.8 Article

LipidBlast in silico tandem mass spectrometry database for lipid identification

期刊

NATURE METHODS
卷 10, 期 8, 页码 755-+

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2551

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资金

  1. National Research Foundation of Korea
  2. Ministry of Education, Science and Technology [2010-0021368]
  3. Korea Healthcare Technology R&D Project, Ministry of Health and Welfare [A103017]
  4. Cooperative Research Program for Agriculture Science and Technology Development, Rural Development Administration, Republic of Korea [PJ00948604]
  5. US National Science Foundation [MCB 1139644]
  6. US National Institutes of Health [P20 HL113452, U24 DK097154]
  7. Direct For Biological Sciences
  8. Division Of Integrative Organismal Systems [1139644] Funding Source: National Science Foundation
  9. Korea Health Promotion Institute [HN10C0033010013, A103017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  10. National Research Foundation of Korea [2010-0021368] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  11. Rural Development Administration (RDA), Republic of Korea [PJ009486042013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Current tandem mass spectral libraries for lipid annotations in metabolomics are limited in size and diversity. We provide a freely available computer-generated tandem mass spectral library of 212,516 spectra covering 119,200 compounds from 26 lipid compound classes, including phospholipids, glycerolipids, bacterial lipoglycans and plant glycolipids. We show platform independence by using tandem mass spectra from 40 different mass spectrometer types including low-resolution and high-resolution instruments.

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