4.8 Article

A database of Caenorhabditis elegans behavioral phenotypes

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NATURE METHODS
卷 10, 期 9, 页码 877-+

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NATURE PORTFOLIO
DOI: 10.1038/NMETH.2560

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  1. MRC [MC-A022-5PB91]
  2. National Institute on Drug Abuse, US National Institutes of Health [DA018341]
  3. Gates Cambridge Scholarship
  4. Human Frontier Science Program
  5. MRC [MC_U105185857] Funding Source: UKRI
  6. Medical Research Council [MC_U105185857] Funding Source: researchfish

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Using low-cost automated tracking microscopes, we have generated a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype. The growing database currently consists of 9,203 short videos segmented to extract behavior and morphology features, and these videos and feature data are available online for further analysis. The database also includes summary statistics for 702 measures with statistical comparisons to wild-type controls so that phenotypes can be identified and understood by users.

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